Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China.
J Neural Transm (Vienna). 2012 Mar;119(3):387-94. doi: 10.1007/s00702-011-0714-6. Epub 2011 Oct 9.
Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. Therefore, we performed this meta-analysis in order to evaluate the relationship between ApoE gene polymorphism and susceptibility to vascular dementia in Chinese population by pooling data from all relevant case-control studies published domestically and abroad from January 1990 to May 2011. 18 case-control studies were selected. Meta-analysis results showed that the pooled OR value of vascular dementia subjects in Chinese population with ε4 allele carriers was 2.07 [95% CI (1.69, 2.53)], and the pooled OR value of vascular dementia subjects with E4/E4 genotype was 3.34 [95% CI (1.89, 5.88)]. These results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population. The subject with at least one ε4 allele or E4/E4 genotype has higher risk suffering from vascular dementia than others.
血管性痴呆是痴呆的第二大常见病因,仅次于阿尔茨海默病。载脂蛋白 E(ApoE)基因多态性作为血管性痴呆的危险因素之一,已被提出,但即使在中国人种中,遗传关联研究的直接证据仍不确定。因此,我们进行了这项荟萃分析,以评估 ApoE 基因多态性与中国人群血管性痴呆易感性之间的关系,方法是合并国内外自 1990 年 1 月至 2011 年 5 月发表的所有相关病例对照研究的数据。共纳入 18 项病例对照研究。荟萃分析结果表明,ε4 等位基因携带者的中国人群血管性痴呆患者的合并 OR 值为 2.07(95%CI:1.69,2.53),E4/E4 基因型的血管性痴呆患者的合并 OR 值为 3.34(95%CI:1.89,5.88)。这些结果表明 ApoE 多态性与中国人群血管性痴呆易感性显著相关。至少携带一个 ε4 等位基因或 E4/E4 基因型的个体患血管性痴呆的风险更高。