Munteanu M G, Vlahovicek K, Parthasarathy S, Simon I, Pongor S
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy.
Trends Biochem Sci. 1998 Sep;23(9):341-7. doi: 10.1016/s0968-0004(98)01265-1.
Local bending phenomena can be predicted by elastic models that incorporate sequence-dependent anisotropic-bendability (SDAB). SDAB models consider DNA to be an initially straight, segmented, elastic rod, in which the flexibility of each segment is greater towards the major groove than it is in other directions. While local bending can be predicted by static-geometry models as well, SDAB models, in addition, qualitatively explain such phenomena as the affinity of protein binding and kinking. A set of prediction tools is available at http:/(/)www.icgeb.trieste.it/dna.
局部弯曲现象可以通过纳入序列依赖性各向异性弯曲性（SDAB）的弹性模型来预测。SDAB模型将DNA视为一根初始笔直、分段的弹性杆，其中每个片段向大沟方向的柔韧性比其他方向更大。虽然局部弯曲也可以通过静态几何模型来预测，但SDAB模型此外还能定性解释诸如蛋白质结合亲和力和扭结等现象。可在http:/(/)www.icgeb.trieste.it/dna获取一套预测工具。
