Dube S, Kung H J, Bender W, Davidson N, Ostertag W
J Virol. 1976 Oct;20(1):264-72. doi: 10.1128/JVI.20.1.264-272.1976.
Electron microscope and gel electrophoresis studies show that the high-molecular-weight (50 to 70S) RNA extract from Friend virus (FV) is a dimer with the same basic structure previously observed for the RNAs from RD-114 virus, baboon virus, and woolly monkey virus. This observation greatly strengthens the inference that the dimer structure is a general characteristic of the RNAs of all mammalian type C viruses. The FV dimer is slightly less stable than the RNA dimer of woolly monkey virus, which is, in turn, much less stable than those of RD-114 and baboon virus. There are three FV monomer components, small (S), medium (M), and large (L), with molecular lengths of 6.7 +/- 0.6, 7.7 +/- 0.6, and 9.5 +/- 0.6 kilobases, respectively. There are approximately equal amounts of the S and M components and much less of the L component. Most of the dimers are homodimers (SS, MM, and LL). The frequency of heterodimers (SM, SL, ML) is much less than expected for a random assortment model.
电子显微镜和凝胶电泳研究表明，从弗瑞德病毒（FV）中提取的高分子量（50至70S）RNA是一种二聚体，其基本结构与先前在RD - 114病毒、狒狒病毒和绒毛猴病毒的RNA中观察到的相同。这一观察结果极大地强化了二聚体结构是所有哺乳动物C型病毒RNA的普遍特征这一推断。FV二聚体的稳定性略低于绒毛猴病毒的RNA二聚体，而绒毛猴病毒的RNA二聚体又远不如RD - 114病毒和狒狒病毒的RNA二聚体稳定。FV有三种单体成分，即小（S）、中（M）和大（L），分子长度分别为6.7±0.6、7.7±0.6和9.5±0.6千碱基。S和M成分的量大致相等，而L成分的量则少得多。大多数二聚体是同型二聚体（SS、MM和LL）。异型二聚体（SM、SL、ML）的频率远低于随机排列模型的预期值。
