Bender W, Chien Y H, Chattopadhyay S, Vogt P K, Gardner M B, Davidson N
J Virol. 1978 Mar;25(3):888-96. doi: 10.1128/JVI.25.3.888-896.1978.
Several 50 to 70S tumor viral RNAs have previously been shown by electron microscopy to be dimers, with the two monomer subunits joined near their 5' ends. Five additional naturally occurring type C RNA tumor viruses have now been examined: AKR, and endogenous murine ecotropic virus; NZB, an endogenous murine xenotropic virus; and ecotropic and an amphotropic virus isolated from a wild mouse; and the avian reticuloendotheliosis virus (REV). All five 50 to 70S RNAs have similar 5'-to-5' dimer structures. Therefore, the observations support the hypothesis that the dimer linkage is a structural feature common to all type C mammalian viruses. REV is the first example of an avian virus with a clear 5'-to 5' dimer linkage. All of the mammalian viral RNAs, but not REV, showed symmetrically placed loops in each subunit of the dimer. Possible molecular structures and biological functions of the dimer linkages and loops are discussed.
先前通过电子显微镜已证实，几种50到70S的肿瘤病毒RNA是二聚体，两个单体亚基在其5'端附近相连。现在已经检测了另外五种天然存在的C型RNA肿瘤病毒：AKR，一种内源性小鼠嗜亲性病毒；NZB，一种内源性小鼠嗜异性病毒；从一只野生小鼠中分离出的嗜亲性病毒和一种兼嗜性病毒；以及禽网状内皮组织增生症病毒（REV）。所有这五种50到70S的RNA都具有相似的5'-至-5'二聚体结构。因此，这些观察结果支持这样一种假说，即二聚体连接是所有C型哺乳动物病毒共有的结构特征。REV是具有明确的5'-至-5'二聚体连接的禽病毒的首个例子。所有哺乳动物病毒RNA，而非REV，在二聚体的每个亚基中都显示出对称排列的环。文中讨论了二聚体连接和环可能的分子结构及生物学功能。
