McCance-Katz E F, Kosten T R, Jatlow P
Yale Psychiatric Institute, New Haven, CT, USA.
Drug Alcohol Depend. 1998 Sep 1;52(1):27-39. doi: 10.1016/s0376-8716(98)00050-7.
Disulfiram (Antabuse) is being used in outpatient clinical trials to determine its efficacy as a treatment for cocaine dependence. This inpatient randomized, double-blind, placebo-controlled, within-subjects study was conducted to determine whether disulfiram (placebo, 250 or 500 mg/day) alters responses to acute intranasal cocaine (placebo, 1 or 2 mg/kg) administration. Effects of disulfiram on cocaine pharmacokinetics, physiological, and behavioral responses were determined. Disulfiram treatment increased plasma cocaine concentrations three to six times and significantly increased cocaine-associated cardiovascular responses, but did not significantly alter behavioral responses to cocaine. These interactions should be considered in the decision regarding disulfiram treatment in cocaine dependent patients.
双硫仑（安塔布司）正在门诊临床试验中用于确定其作为治疗可卡因依赖的疗效。本项住院患者随机、双盲、安慰剂对照、受试者内研究旨在确定双硫仑（安慰剂、250或500毫克/天）是否会改变对急性鼻内给予可卡因（安慰剂、1或2毫克/千克）的反应。测定了双硫仑对可卡因药代动力学、生理和行为反应的影响。双硫仑治疗使血浆可卡因浓度增加了三到六倍，并显著增加了与可卡因相关的心血管反应，但并未显著改变对可卡因的行为反应。在决定对可卡因依赖患者进行双硫仑治疗时应考虑这些相互作用。
