Tokar' A V
Kardiologiia. 1976 Jul;16(7):57-64.
Systolic hypertension was studied in 92 patients, aged 60 to 103 years, some of them being followed-up for periods up to 8 years. The examination included that of haemodynamics, functional state of the heart and gas composition of blood (by the dye dilution technique, polycardiography, teleradiography, Sechenov and van Slyke methods, the micro-Astrup technique). The previously reported concept of the author was proved, i.e. the immediate haemodynamic cause of arterial pressure elevation in this pathology consists in an increased cardiac output against the background of an increased total elastic resistance of the arterial system. The elevation of the cardiac output is due not only to the neuro-humoral disorders in the regulation of arterial pressure in old age, but also to the adaptational factors directed to the improvement of oxygen transport and consumption by the tissues when the premeability of the vascular-tissuemembranes is impaired.
对92名年龄在60至103岁之间的患者进行了收缩期高血压研究，其中一些患者随访了长达8年。检查包括血流动力学、心脏功能状态和血液气体成分（采用染料稀释技术、多导心电图、远距放射照相、谢切诺夫法和范斯莱克法、微量阿斯屠普技术）。作者先前报道的概念得到了证实，即在这种病理情况下动脉压升高的直接血流动力学原因在于在动脉系统总弹性阻力增加的背景下心输出量增加。心输出量的增加不仅归因于老年时动脉压调节中的神经体液紊乱，还归因于当血管组织膜通透性受损时旨在改善组织氧运输和消耗的适应性因素。
