Germer C, Isbert C M, Albrecht D, Ritz J P, Schilling A, Roggan A, Wolf K J, Müller G, Buhr H
Department of General, Vascular, and Thoracic Surgery, University Hospital, Benjamin Franklin Freie Universität Berlin, Hindenburgdamm 30, 12200 Germany.
Surg Endosc. 1998 Nov;12(11):1317-25. doi: 10.1007/s004649900849.
To evaluate gadolinium (Gd)-diethylenetriamine-pentaacetic-acid (DTPA)-enhanced magnetic resonance imaging (MRI) for follow-up monitoring of laser-induced thermotherapy (LITT) and to determine a useful examination schedule.
LITT of the liver was performed in 55 rabbits using a neodymium: yttrium-aluminum-garnet (Nd:YAG) laser (4-W power output, 840-s exposure time). Gd-DTPA MRI and histologic examinations were performed at different times (0-168 days).
Laser-induced lesions underwent regeneration and volume size reduction (69% after 168 days). The correlation coefficient (MR vs. macroscopic analysis) for the mean lesion diameter was r = 0.96. Histology of lesions comprised the four zones that correlated best with MRI findings. Coagulation necroses immediately after LITT was seen as an area of no enhancement on Gd-DTPA MRI. Circular enhancement was first seen 72-96 h after LITT, which was due to early mesenchymal proliferation.
Gd-DTPA MRI is a good monitoring procedure for LITT. MRI should be performed 24 and 96 h after LITT.
评估钆（Gd）-二乙烯三胺五乙酸（DTPA）增强磁共振成像（MRI）在激光诱导热疗（LITT）随访监测中的应用，并确定一个有用的检查时间表。
使用钕：钇铝石榴石（Nd：YAG）激光（输出功率4W，暴露时间840秒）对55只兔子进行肝脏LITT。在不同时间（0 - 168天）进行Gd-DTPA MRI和组织学检查。
激光诱导的病变发生再生且体积减小（168天后减小69%）。平均病变直径的相关系数（MR与宏观分析）为r = 0.96。病变的组织学包括与MRI结果相关性最佳的四个区域。LITT后立即出现的凝固性坏死在Gd-DTPA MRI上表现为无强化区域。LITT后72 - 96小时首次出现环形强化，这是由于早期间充质增生所致。
Gd-DTPA MRI是LITT的良好监测方法。MRI应在LITT后24小时和96小时进行。
