激光诱导热疗治疗肝转移。钆-二乙三胺五乙酸增强磁共振成像与组织形态学结果的相关性以确定随访监测标准。

Laser-induced thermotherapy for the treatment of liver metastasis. Correlation of gadolinium-DTPA-enhanced MRI with histomorphologic findings to determine criteria for follow-up monitoring.

作者信息

Germer C, Isbert C M, Albrecht D, Ritz J P, Schilling A, Roggan A, Wolf K J, Müller G, Buhr H

机构信息

Department of General, Vascular, and Thoracic Surgery, University Hospital, Benjamin Franklin Freie Universität Berlin, Hindenburgdamm 30, 12200 Germany.

出版信息

Surg Endosc. 1998 Nov;12(11):1317-25. doi: 10.1007/s004649900849.

DOI:10.1007/s004649900849

PMID:9788855

Abstract

PURPOSE

To evaluate gadolinium (Gd)-diethylenetriamine-pentaacetic-acid (DTPA)-enhanced magnetic resonance imaging (MRI) for follow-up monitoring of laser-induced thermotherapy (LITT) and to determine a useful examination schedule.

METHODS

LITT of the liver was performed in 55 rabbits using a neodymium: yttrium-aluminum-garnet (Nd:YAG) laser (4-W power output, 840-s exposure time). Gd-DTPA MRI and histologic examinations were performed at different times (0-168 days).

RESULTS

Laser-induced lesions underwent regeneration and volume size reduction (69% after 168 days). The correlation coefficient (MR vs. macroscopic analysis) for the mean lesion diameter was r = 0.96. Histology of lesions comprised the four zones that correlated best with MRI findings. Coagulation necroses immediately after LITT was seen as an area of no enhancement on Gd-DTPA MRI. Circular enhancement was first seen 72-96 h after LITT, which was due to early mesenchymal proliferation.

CONCLUSIONS

Gd-DTPA MRI is a good monitoring procedure for LITT. MRI should be performed 24 and 96 h after LITT.

摘要

目的

评估钆（Gd）-二乙烯三胺五乙酸（DTPA）增强磁共振成像（MRI）在激光诱导热疗（LITT）随访监测中的应用，并确定一个有用的检查时间表。

方法

使用钕：钇铝石榴石（Nd：YAG）激光（输出功率4W，暴露时间840秒）对55只兔子进行肝脏LITT。在不同时间（0 - 168天）进行Gd-DTPA MRI和组织学检查。

结果

激光诱导的病变发生再生且体积减小（168天后减小69%）。平均病变直径的相关系数（MR与宏观分析）为r = 0.96。病变的组织学包括与MRI结果相关性最佳的四个区域。LITT后立即出现的凝固性坏死在Gd-DTPA MRI上表现为无强化区域。LITT后72 - 96小时首次出现环形强化，这是由于早期间充质增生所致。