Kahn T, Harth T, Bettag M, Schwabe B, Ulrich F, Schwarzmaier H J, Mödder U
Institute of Diagnostic Radiology, Heinrich-Heine-University, Düsseldorf, Germany.
J Magn Reson Imaging. 1997 Jan-Feb;7(1):226-9. doi: 10.1002/jmri.1880070135.
The purpose of this study was to investigate the potential value of i.v. gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) applied before MRI-guided laser-induced interstitial thermotherapy (LITT) of brain tumors without original enhancement, especially in defining total lesion size during therapy. MRI-guided LITT was performed on two patients with astrocytoma WHO II. For both patients, Gd-DTPA was administered intravenously after a first irradiation period and LITT was continued after pulling back the light guide to coagulate the upper parts of the tumor. In both patients, the whole irreversible damaged zone of the second irradiation period after Gd-DTPA showed an intense increase of signal intensity. The spatial expansion correlated with the diameter of an enhancing rim after Gd-DTPA on follow-up studies. Our preliminary results indicate that the application of Gd-DTPA before MRI-guided LITT may be of value in defining exactly the size of the irreversible damaged zone during therapy in nonenhancing brain tumors.
本研究的目的是探讨静脉注射钆喷酸葡胺（Gd-DTPA）在MRI引导下对无原发强化的脑肿瘤进行激光间质热疗（LITT）之前的潜在价值，尤其是在确定治疗期间的总病变大小方面。对两名WHO II级星形细胞瘤患者进行了MRI引导下的LITT。对于这两名患者，在第一个照射期后静脉注射Gd-DTPA，在将光导撤回以凝固肿瘤上部后继续进行LITT。在两名患者中，Gd-DTPA注射后第二个照射期的整个不可逆损伤区信号强度显著增加。在后续研究中，空间扩展与Gd-DTPA注射后强化边缘的直径相关。我们的初步结果表明，在MRI引导下的LITT之前应用Gd-DTPA可能有助于准确确定非强化性脑肿瘤治疗期间不可逆损伤区的大小。
