Guido M, Rugge M, Colombari R, Cecchetto A, Scarpa A, Cadrobbi P
Pathology Department, University of Padova, Italy.
Ital J Gastroenterol Hepatol. 1998 Aug;30(4):414-7.
The natural course of chronic hepatitis C virus infection after hepatitis B virus superinfection is not clear since it is difficult to determine the chronology of the double infections. We report on a case of de novo hepatitis B virus infection in the course of chronic untreated hepatitis C, in which the time of hepatitis B virus infection is actually known. The patient eliminated HCV-RNA, both from serum and from liver tissue, soon after the clinical onset of the acute hepatitis B. Liver histology featured hepatitis with severe portal inflammation and high-grade periportal and intralobular necro-inflammatory lesions. This observation demonstrates that hepatitis C virus replication can be promptly and spontaneously suppressed by acute hepatitis B virus superinfection.
由于难以确定双重感染的时间顺序，乙型肝炎病毒（HBV）重叠感染后慢性丙型肝炎病毒（HCV）感染的自然病程尚不清楚。我们报告了1例慢性未经治疗的丙型肝炎病程中发生的新发HBV感染病例，其中HBV感染时间确切已知。急性乙型肝炎临床发病后不久，患者血清和肝组织中的HCV-RNA均消失。肝脏组织学特征为肝炎伴严重门静脉炎症以及重度汇管区周围和小叶内坏死性炎症病变。这一观察结果表明，急性HBV重叠感染可迅速且自发地抑制HCV复制。
