Magura S, Kang S Y, Rosenblum A, Handelsman L, Foote J
National Development and Research Institutes, Inc., New York, NY 10048, USA.
J Addict Dis. 1998;17(3):49-61. doi: 10.1300/J069v17n03_05.
Psychiatric comorbidity was examined for a sample of 212 methadone patients dually addicted to opiates and cocaine, focusing on gender differences. Diagnoses were determined by the SCID for DSM-III-R. Men displayed more lifetime (but not current) substance use disorders, while women displayed more lifetime and current non-substance use disorders. There were several significant interactions among psychiatric disorders and gender. Women were more likely than men to present with concurrent mood and anxiety disorders. Women with ASPD were unlikely to have alcohol use disorder, but likely to have opioid use disorder. Men with anxiety were likely to be diagnosed with ASPD. Treatment implications of the findings are discussed.
对212名同时对鸦片类药物和可卡因成瘾的美沙酮患者样本进行了精神疾病共病情况检查，重点关注性别差异。诊断由针对《精神疾病诊断与统计手册第三版修订本》（DSM-III-R）的结构性临床访谈（SCID）确定。男性表现出更多的终生（而非当前）物质使用障碍，而女性表现出更多的终生和当前非物质使用障碍。精神疾病和性别之间存在若干显著的相互作用。女性比男性更有可能同时出现情绪和焦虑障碍。患有反社会人格障碍（ASPD）的女性不太可能患有酒精使用障碍，但可能患有阿片类药物使用障碍。患有焦虑症的男性很可能被诊断为反社会人格障碍。文中讨论了这些研究结果对治疗的启示。
