Monda M, Sullo A, De Luca V, Viggiano A
Department of Human Physiology and Integrated Biological Functions, Second University of Naples, Italy.
Acta Physiol Scand. 1998 Aug;163(4):379-84. doi: 10.1046/j.1365-201X.1998.t01-1-00353.x.
The firing rate of the nerves innervating interscapular brown adipose tissue, temperatures of colon and interscapular brown adipose tissue, heart rate and oxygen consumption were monitored in urethane-anaesthetized male Sprague-Dawley rats fed with a sucrose rich diet. These variables were measured for 40 min before (baseline values) and 40 min after a 56 ng muscimol injection into the posterior hypothalamus. The same variables were monitored in other rats fed with a laboratory standard diet. Saline was injected into the posterior hypothalamus of control rats fed with sucrose or standard diet. Muscimol injection induced a decrease in firing rate, interscapular brown adipose tissue and colonic temperatures and oxygen consumption. This reduction was more evident in the rat fed with a sucrose rich diet than animals fed with standard diet. The kind of diet did not modify the decrease in heart rate induced by muscimol. These findings suggest that a sucrose rich diet modifies GABA-ergic responses to muscimol injection into the posterior hypothalamus.
在给食用富含蔗糖饮食的氨基甲酸乙酯麻醉的雄性斯普拉格-道利大鼠中，监测支配肩胛间棕色脂肪组织的神经放电频率、结肠和肩胛间棕色脂肪组织的温度、心率和耗氧量。在向下丘脑后部注射56纳克蝇蕈醇之前（基线值）和之后40分钟测量这些变量。在其他食用实验室标准饮食的大鼠中监测相同的变量。向食用蔗糖或标准饮食的对照大鼠的下丘脑后部注射生理盐水。注射蝇蕈醇导致放电频率、肩胛间棕色脂肪组织和结肠温度以及耗氧量降低。这种降低在食用富含蔗糖饮食的大鼠中比食用标准饮食的动物更明显。饮食种类并未改变蝇蕈醇引起的心率下降。这些发现表明，富含蔗糖的饮食会改变对向下丘脑后部注射蝇蕈醇的GABA能反应。
