Monda M, Amaro S, Sullo A, De Luca B
Department of Human Physiology and Integrated Biological Functions F. Bottazzi, Second University of Naples, Italy.
Brain Res Bull. 1995;37(6):575-80. doi: 10.1016/0361-9230(95)00032-a.
The firing rate of the nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (TIBAT and Tc), heart rate, and oxygen (O2) consumption were monitored in urethane-anesthetized male Sprague-Dawley rats. These variables were measured for 40 min before (baseline values) and 40 min after a 56 ng muscimol injection in the posterior hypothalamus and an intracerebroventricular administration of 500 ng prostaglandin E1 (PGE1). The same variables were monitored in other rats with muscimol injection or PGE1 administration alone. No drug was injected in control rats. The results show that muscimol injection reduces the increases in firing rate, TIBAT, Tc, heart rate, O2 consumption induced by PGE1. These findings suggest that GABAergic tone in the posterior hypothalamus is important in the control of thermogenic changes induced by PGE1.
在氨基甲酸乙酯麻醉的雄性Sprague-Dawley大鼠中，监测支配肩胛间棕色脂肪组织（IBAT）的神经放电频率、IBAT和结肠温度（TIBAT和Tc）、心率以及氧气（O₂）消耗量。在丘脑后部下注射56 ng蝇蕈醇并脑室内注射500 ng前列腺素E1（PGE1）之前（基线值）和之后40分钟测量这些变量。在单独注射蝇蕈醇或PGE1的其他大鼠中监测相同的变量。对照大鼠不注射任何药物。结果表明，注射蝇蕈醇可降低PGE1诱导的放电频率、TIBAT、Tc、心率、O₂消耗量的增加。这些发现表明，丘脑后部的γ-氨基丁酸能张力在控制PGE1诱导的产热变化中很重要。
