Monda M, Viggiano An, Viggiano Al, Viggiano E, Messina G, Tafuri D, De Luca V
Department of Experimental Medicine, Section of Human Physiology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy.
Neuropeptides. 2006 Oct;40(5):357-63. doi: 10.1016/j.npep.2006.07.003. Epub 2006 Sep 28.
Since no experiment regarding a possible relation between quetiapine and orexin A has been reported in international literature, this experiment tested the effect of quetiapine on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT, colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before an injection of orexin A (1.5 nmol) into the lateral cerebral ventricle and over a period of 150 min after the injection. The same variables were monitored in rats with an intraperitoneal administration of quetiapine (5 or 10 mg/kg bw), injected 30 min before the orexin administration. The results show that orexin A increases the sympathetic firing rate, IBAT, colonic temperatures and heart rate. This increase is delayed or reduced by the injection of quetiapine. These findings indicate that quetiapine affects the complex reactions related to activation of orexinergic system. Possible influences on the control of body weight and temperature are discussed.
由于国际文献中尚未报道过任何关于喹硫平与食欲素A之间可能存在关系的实验，本实验测试了喹硫平对食欲素A诱导的交感神经和产热效应的影响。在向侧脑室注射食欲素A（1.5纳摩尔）之前以及注射后的150分钟内，监测了乌拉坦麻醉的雄性Sprague-Dawley大鼠中支配肩胛间棕色脂肪组织（IBAT）的交感神经放电频率，同时监测了IBAT、结肠温度和心率。在食欲素给药前30分钟腹腔注射喹硫平（5或10毫克/千克体重）的大鼠中监测相同的变量。结果表明，食欲素A可增加交感神经放电频率、IBAT、结肠温度和心率。注射喹硫平会使这种增加延迟或减弱。这些发现表明，喹硫平会影响与食欲素能系统激活相关的复杂反应。文中还讨论了其对体重和体温控制的可能影响。
