Bernard O
Service d'hépatologie pédiatrique, hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Arch Pediatr. 1998 Sep;5(9):1031-5. doi: 10.1016/S0929-693X(98)80020-1.
Neonatal cholestasis should be considered in every baby in whom jaundice persists after day 10. Biliary atresia is the main cause of neonatal cholestasis and its prognosis is highly dependent on the early age at which surgery is performed. Finding the cause of cholestasis before day 30 is therefore crucial. This relies, in most instances, on simple clinical, biochemical, radiological and ophthalmologic criteria, the most important of which is a careful study of the degree and duration of stool discoloration.
对于出生10天后黄疸仍持续不退的每一个婴儿,都应考虑新生儿胆汁淤积症。胆道闭锁是新生儿胆汁淤积症的主要病因,其预后高度依赖于手术进行的早期年龄。因此,在30天前找出胆汁淤积的病因至关重要。在大多数情况下,这依赖于简单的临床、生化、放射学和眼科标准,其中最重要的是仔细研究粪便颜色改变的程度和持续时间。