Ono Y, Aoki S, Ohnishi K, Yasuda T, Kawano K, Tsukada Y
Department of Internal Medicine, Sapporo Shakaihoken General Hospital, Japan.
Diabetes Res Clin Pract. 1998 Aug;41(2):131-7. doi: 10.1016/s0168-8227(98)00074-6.
We determined serum advanced glycation end-products (AGE) levels in patients with NIDDM and evaluated the relationship between these levels and diabetic complications. The subjects consisted of 125 patients (mean age, 59.2 +/- 11.1 years, duration of diabetes 11.6 +/- 8.9 years, mean HbA1c, 6.8 +/- 1.0%) with stable blood sugar control. Sixty-three healthy volunteers (mean age, 58.3 +/- 12.7 years) served as controls. Serum AGE were measured by a newly developed ELISA method. Serum AGE levels were significantly higher in the diabetic group compared with the normal control group (7.2 +/- 14.6 vs. 3.3 +/- 1.0 mU/ml, P < 0.05). Significant correlations were seen between serum AGE and the degree of diabetic nephropathy. Serum AGE levels of diabetic patients with proliferative retinopathy were significantly higher than those of patients without proliferative retinopathy (5.7 +/- 1.8 vs. 3.1 +/- 1.0 mU/ml, P < 0.025) in the patient groups whose serum creatinine levels were between 2.0 and 3.9 mg/dl, although serum creatinine levels of both groups were not significantly different. Serum AGE levels reflected the severity of diabetic complications, including nephropathy and retinopathy.
我们测定了非胰岛素依赖型糖尿病（NIDDM）患者血清晚期糖基化终产物（AGE）水平，并评估了这些水平与糖尿病并发症之间的关系。研究对象包括125例血糖控制稳定的患者（平均年龄59.2±11.1岁，糖尿病病程11.6±8.9年，平均糖化血红蛋白[HbA1c]为6.8±1.0%）。63名健康志愿者（平均年龄58.3±12.7岁）作为对照。采用新开发的酶联免疫吸附测定（ELISA）方法检测血清AGE。糖尿病组血清AGE水平显著高于正常对照组（7.2±14.6对3.3±1.0 mU/ml，P<0.05）。血清AGE与糖尿病肾病程度之间存在显著相关性。在血清肌酐水平介于2.0至3.9 mg/dl之间的患者组中，患有增殖性视网膜病变糖尿病患者的血清AGE水平显著高于无增殖性视网膜病变患者（5.7±1.8对3.1±1.0 mU/ml，P<0.025），尽管两组的血清肌酐水平无显著差异。血清AGE水平反映了糖尿病并发症（包括肾病和视网膜病变）的严重程度。
