Shih C M, Wang C C
Department of Parasitology and Tropical Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Am J Trop Med Hyg. 1998 Oct;59(4):509-12. doi: 10.4269/ajtmh.1998.59.509.
We report the ability of azithromycin in combination with quinine to eliminate the Babesia infection in a native Taiwanese woman. Failure of elimination of the babesial infection was observed two weeks after treating with standard regimen of oral quinine plus intravenous clindamycin for a 10-day course of therapy. Azithromycin in place of clindamycin was administered for another 10-day course of therapy two months following initial treatment. Clearance of Babesia parasites was observed and verified by hamster inoculation. These results suggest that azithromycin plus quinine should be considered as an alternative therapy for human babesiosis, especially in the failure of treatment with standard regimens.
我们报告了阿奇霉素联合奎宁清除一名台湾本地女性巴贝斯虫感染的能力。在用口服奎宁加静脉注射克林霉素的标准方案治疗10天后，两周后观察到巴贝斯虫感染清除失败。初始治疗两个月后，用阿奇霉素替代克林霉素进行了另一个为期10天的疗程治疗。通过仓鼠接种观察并证实了巴贝斯虫寄生虫的清除。这些结果表明，阿奇霉素加奎宁应被视为人类巴贝斯虫病的替代疗法，特别是在标准方案治疗失败的情况下。
