CREB1编码一种核激活因子、一种阻遏蛋白和一种细胞质调节剂，它们形成一个对长期易化至关重要的调节单元。

CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation.

作者信息

Bartsch D, Casadio A, Karl K A, Serodio P, Kandel E R

机构信息

Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York 10032, USA.

出版信息

Cell. 1998 Oct 16;95(2):211-23. doi: 10.1016/s0092-8674(00)81752-3.

DOI:10.1016/s0092-8674(00)81752-3

PMID:9790528

Abstract

Although CREB seems to be important for memory formation, it is not known which of the isoforms of CREB, CREM, or ATF1 are expressed in the neurons that undergo long-term synaptic changes and what roles they have in memory formation. We have found a single Aplysia CREB1 gene homologous to both mammalian CREB and CREM and have characterized in the sensory neurons that mediate gill-withdrawal reflex the expression and function of the three proteins that it encodes: CREB1a, CREB1b, and CREB1c. CREB1a is a transcriptional activator that is both necessary and, upon phosphorylation, sufficient for long-term facilitation. CREB1b is a repressor of long-term facilitation. Cytoplasmic CREB1c modulates both the short- and long-term facilitation. Thus, in the sensory neurons, CREB1 encodes a critical regulatory unit converting short- to long-term synaptic changes.

摘要

尽管CREB似乎对记忆形成很重要，但尚不清楚CREB、CREM或ATF1的哪些亚型在经历长期突触变化的神经元中表达，以及它们在记忆形成中发挥什么作用。我们发现了一个与哺乳动物CREB和CREM同源的单一海兔CREB1基因，并在介导鳃收缩反射的感觉神经元中对其编码的三种蛋白质CREB1a、CREB1b和CREB1c的表达和功能进行了表征。CREB1a是一种转录激活因子，对长期易化作用既是必需的，磷酸化后也是充分的。CREB1b是长期易化作用的抑制因子。细胞质中的CREB1c调节短期和长期易化作用。因此，在感觉神经元中，CREB1编码一个关键的调节单元，将短期突触变化转化为长期突触变化。