Vetter W, Vetter H, Beckerhoff R, Redlich B, Cottier P, Siegenthaler W
Klin Wochenschr. 1976 Jul 15;54(14):661-3. doi: 10.1007/BF01469145.
To investigate the role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome two patients with hypercorticism were infused with 20 mg saralasin (1-sar-8-ala-angiotensin II) over a period of 30 minutes under constant blood pressue control. In addition, one patient with primary aldosteronism, an established form of mineralocorticoid hypertension, served as control. Neither in the two patients with Cushing's syndrome nor in the patient with primary aldosteronism could a blood pressure lowering effect of saralasin be observed. In the two patients with hypercoritcism both renin activity and plasma aldosterone increased during saralasin infusion. The patient with primary aldosteronism only showed a weak increase in plasma aldosterone concentration.
为研究肾素血管紧张素系统在库欣综合征高血压发病机制中的作用，在血压恒定控制下，对两名皮质醇增多症患者在30分钟内输注20毫克沙拉新（1-沙拉-8-丙氨酸-血管紧张素II）。此外，一名原发性醛固酮增多症患者（一种已确定的盐皮质激素性高血压形式）作为对照。在两名库欣综合征患者和原发性醛固酮增多症患者中均未观察到沙拉新的降压作用。在两名皮质醇增多症患者中，输注沙拉新期间肾素活性和血浆醛固酮均升高。原发性醛固酮增多症患者仅表现出血浆醛固酮浓度的微弱升高。
