Manolitsas T P, Lanham S A, Hitchcock A, Watson R H
Department of Obstetrics and Gynaecology, Princess Anne Hospital, Coxford Road, Southampton, SO16 5YA, United Kingdom.
Gynecol Oncol. 1998 Sep;70(3):428-31. doi: 10.1006/gyno.1998.5058.
In contrast to the strong association between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), the relationship between HPV and squamous epithelial lesions of the ovary is less clear. We report a case of synchronous ovarian and cervical squamous intraepithelial neoplasia. To investigate the possible association between HPV and squamous intraepithelial neoplasia/carcinoma in situ (CIS) of the ovary, DNA was extracted from paraffin-embedded tissues including normal cervix, CIN, CIS from both ovaries, and an area of ovarian endometriosis. All samples were positive for HPV 16 E6 except for one of the two samples from the normal cervical squamous epithelium. These results support the hypothesis that HPV may be involved in the development of ovarian squamous intraepithelial neoplasia.
与人类乳头瘤病毒（HPV）和宫颈上皮内瘤变（CIN）之间的紧密关联形成对比的是，HPV与卵巢鳞状上皮病变之间的关系尚不明确。我们报告了一例同时发生的卵巢和宫颈鳞状上皮内瘤变病例。为了研究HPV与卵巢鳞状上皮内瘤变/原位癌（CIS）之间可能存在的关联，我们从石蜡包埋组织中提取了DNA，这些组织包括正常宫颈、CIN、双侧卵巢的CIS以及一处卵巢子宫内膜异位症区域。除了正常宫颈鳞状上皮的两个样本中的一个外，所有样本的HPV 16 E6均呈阳性。这些结果支持了HPV可能参与卵巢鳞状上皮内瘤变发展的假说。
