Gazenko O G, Demin N N, Panov A N, Rubinskaia N L, Tigranian R A
Kosm Biol Aviakosm Med. 1976 Jul-Aug;10(4):14-9.
On the 2nd postflight day the activity of neutral protamine peptide hydrolase of different compartments of the rat brain did not differ from the control level. With respect to the protein and RNA content and concentration motoneurons of anterior horns of the spinal cord and their glial-cells-satellites of rats exposed to the ground-based synchronous experiment did not differ from those of vivarium controls, except cells of the supraoptic nucleus. That was found on the 2nd and 27th postflight days. On the 2nd postflight day the protein and RNA concentration in neurons decreased and the protein concentration and content in gliocytes lowered; the RNA concentration and content in Purkinje cells of the cerebellum became reduced. On the 27th postflight day the RNA concentration in neurons of the supraoptic nucleus remained diminished whereas the protein content increased; in spinal motoneurons the protein concentration decreased and in adjacent gliocytes the protein concentration and content lowered. All the above changes made no more than 15% of the control values.
在飞行后第2天，大鼠脑不同区域的中性鱼精蛋白肽水解酶活性与对照水平无差异。在地面同步实验中，除视上核细胞外，脊髓前角运动神经元及其卫星胶质细胞的蛋白质、RNA含量和浓度与饲养对照的大鼠无差异。这是在飞行后第2天和第27天发现的。在飞行后第2天，神经元中的蛋白质和RNA浓度降低，神经胶质细胞中的蛋白质浓度和含量降低；小脑浦肯野细胞中的RNA浓度和含量减少。在飞行后第27天，视上核神经元中的RNA浓度仍然降低，而蛋白质含量增加；脊髓运动神经元中的蛋白质浓度降低，相邻神经胶质细胞中的蛋白质浓度和含量降低。上述所有变化均不超过对照值的15%。
