Lutzker S G, Barnard N J
Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08901, USA.
Mol Med Today. 1998 Sep;4(9):404-11. doi: 10.1016/s1357-4310(98)01329-x.
It was recognized in the 1960s that testicular germ cell tumors were curable with chemotherapeutic drugs. Since that time, newer drugs including cisplatin have increased the cure rate of these tumors to over 80%, even in patients with metastatic disease. Germ cell tumors also exhibit a unique biology and genetics that distinguish them from other solid tumors and might contribute to their routine curability.
20世纪60年代人们认识到，睾丸生殖细胞肿瘤可用化疗药物治愈。从那时起，包括顺铂在内的新药已将这些肿瘤的治愈率提高到80%以上，即使是转移性疾病患者也是如此。生殖细胞肿瘤还表现出独特的生物学和遗传学特征，这使它们有别于其他实体瘤，可能也是它们通常可治愈的原因。
