Smolarek T A, Blough R I, Foster R S, Ulbright T M, Palmer C G, Heerema N A
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA.
Cancer Genet Cytogenet. 1999 Jan 1;108(1):57-69. doi: 10.1016/s0165-4608(98)00113-7.
Cytogenetic analyses of 85 testicular germ cell tumors, of which 54 were karyotypically abnormal, showed recurrent breakpoints at chromosome bands 1p36, 1p13-1qh, 11q23, 19q13, and the pericentromeric regions of the acrocentric chromosomes. Postchemotherapy tumors had significantly more rearrangements of bands 3p25-p26, 6q16-q21, 8p22-p23 when compared with untreated tumors, while untreated tumors had more rearrangements of 9p22-p24 when compared with postchemotherapy tumors. Frequent breakpoints also were identified at 15q15 and 9qh in untreated tumors. Tumors of different histopathology, clinical stage, and treatment status showed no significant differences in the frequencies of i(12p)-positive and i(12p)-negative tumors.
对85例睾丸生殖细胞肿瘤进行细胞遗传学分析，其中54例核型异常，结果显示在染色体带1p36、1p13 - 1qh、11q23、19q13以及近端着丝粒染色体的着丝粒周围区域存在反复出现的断点。与未治疗的肿瘤相比，化疗后肿瘤在3p25 - p26、6q16 - q21、8p22 - p23带的重排明显更多，而与化疗后肿瘤相比，未治疗的肿瘤在9p22 - p24带的重排更多。在未治疗的肿瘤中，还在15q15和9qh处发现了频繁的断点。不同组织病理学、临床分期和治疗状态的肿瘤在i(12p)阳性和i(12p)阴性肿瘤的频率上没有显著差异。
