Tran P D, Leclerc A, Chastang J F, Goldberg M
INSERM U 88, Hôpital National de Saint-Maurice, France.
Eur J Epidemiol. 1998 Sep;14(6):535-43. doi: 10.1023/a:1007437517370.
the study was set up to explore regional disparities in France in the annual prevalence of cardiovascular risk factors (hypertension, high lipids, obesity, diabetes and tobacco consumption) and protective factors (alcohol intake) in members of the GAZEL Cohort and to determine which, if any, risk factors followed the same north-south gradient as the one known for cardiovascular mortality.
the population studied comprised 18,070 subjects aged from 35 to 50 years, employed by the French national gas and electricity company. Every year from 1989 to 1993 they received a self-administered questionnaire by mail. From the replies, differences in risk factor prevalence were evaluated by an odds ratio adjusted for sex and age, using a marginal model.
a regional effect was found (p < 0.001) for arterial hypertension, with high odds ratios in northern France and low ratios in the south east, for high lipids, with high odds ratios in Champagne, the Loire region and Upper Normandy and low ratios in the south east and the Paris area, and for obesity, with high odds ratios in the north and north east and low ratios in the south, south east and west.
these results show a gradient between the north and south east for hypertension, obesity, and to a lesser degree high lipids. This gradient corresponds to the known regional disparities for cardiovascular mortality.
本研究旨在探讨法国GAZEL队列成员中心血管危险因素（高血压、高血脂、肥胖、糖尿病和吸烟）及保护因素（饮酒）的年度患病率的地区差异，并确定是否有任何危险因素呈现出与已知的心血管死亡率相同的南北梯度。
研究人群包括18070名年龄在35至50岁之间、受雇于法国国家天然气和电力公司的受试者。从1989年到1993年，他们每年都会收到一份邮寄的自填问卷。根据回复，使用边际模型通过调整性别和年龄的比值比来评估危险因素患病率的差异。
发现动脉高血压存在地区效应（p < 0.001），法国北部比值比高，东南部比值比低；高血脂方面，香槟、卢瓦尔地区和上诺曼底比值比高，东南部和巴黎地区比值比低；肥胖方面，北部和东北部比值比高，南部、东南部和西部比值比低。
这些结果表明，高血压、肥胖以及程度较轻的高血脂在南北之间存在梯度。这种梯度与已知的心血管死亡率地区差异相对应。
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