Yamamuro T, Nakamura T, Iida H, Kawanabe K, Matsuda Y, Ido K, Tamura J, Senaha Y
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
Biomaterials. 1998 Aug;19(16):1479-82. doi: 10.1016/s0142-9612(98)00062-3.
This paper is a summary of already published papers on the bioactive bone cement (BA cement) which consists of CaO-SiO2-P2O5-MgO-CaF2 (AW glass-ceramic) powder and bisphenol-a-glycidyl methacrylate (Bis-GMA) resin. Two types of BA cement, dough and injection type, were prepared by changing their chemical compositions slightly. They harden in a few minutes exhibiting much lower curing temperature than PMMA cement. They have significantly higher compressive, bending, and tensile strengths than PMMA cement and have a character of bonding directly with bone in 4-8 weeks in vivo. Intercalary prosthetic replacement of the femur and total prosthetic replacement of the hip were performed in dogs using either PMMA cement or BA cement. Mechanical tests demonstrated that fixation strengths of these prostheses with BA cement increased with time and were significantly greater than those with PMMA cement tested at any time. Results of histological examinations showed direct bonding between BA cement and bone, and that the bone trabeculae around BA cement mantle grew with time, while with PMMA cement an intervening soft tissue layer was always observed at the cement-bone interface. BA cement was used in a few aged patients to install a hip prosthesis either in cases of revision or femoral neck fracture. The longest follow-up period of the patient is 4 yrs. The patients have been doing well with no adverse effect of the cement to date.
本文是对已发表的关于生物活性骨水泥（BA骨水泥）的论文的总结，该骨水泥由CaO-SiO2-P2O5-MgO-CaF2（AW玻璃陶瓷）粉末和双酚A-甲基丙烯酸缩水甘油酯（Bis-GMA）树脂组成。通过略微改变其化学成分，制备了两种类型的BA骨水泥，即面团型和注射型。它们在几分钟内硬化，固化温度比聚甲基丙烯酸甲酯（PMMA）骨水泥低得多。它们的抗压、抗弯和抗拉强度明显高于PMMA骨水泥，并且在体内4-8周具有直接与骨结合的特性。使用PMMA骨水泥或BA骨水泥对狗进行了股骨节段性假体置换和髋关节全假体置换。力学测试表明，这些假体与BA骨水泥的固定强度随时间增加，并且在任何时候测试都明显大于与PMMA骨水泥的固定强度。组织学检查结果显示BA骨水泥与骨之间直接结合，并且BA骨水泥套周围的骨小梁随时间生长，而使用PMMA骨水泥时，在水泥-骨界面总是观察到一层中间软组织层。在一些老年患者中，在翻修或股骨颈骨折的情况下使用BA骨水泥安装髋关节假体。患者最长随访期为4年。迄今为止，患者情况良好，骨水泥没有不良反应。
