Seux M L, Thijs L, Forette F, Staessen J A, Birkenhäger W H, Bulpitt C J, Girerd X, Jääskivi M, Vanhanen H, Kivinen P, Yodfat Y, Vänskä O, Antikainen R, Laks T, Webster J R, Hakamäki T, Lehtomäki E, Lilov E, Grigorov M, Janculova K, Halonen K, Kohonen-Jalonen P, Kermowa R, Nachev C, Tuomilehto J
J Hypertens. 1998 Jul;16(7):963-9. doi: 10.1097/00004872-199816070-00009.
To assess cognitive functions and their correlates for a dementia-free cohort of old patients with isolated systolic hypertension.
Cross-sectional data from the randomization period of the European Trial in Elderly with Systolic Hypertension (Syst-Eur Vascular Dementia Project).
Sixteen European countries and Israel.
We studied 2252 patients aged 60-100 years (mean 70).
Mini Mental State Examination (MMSE) and Spearman correlation of MMSE scores to demographic data or blood pressure.
The MMSE was successfully completed for 1474 women and 751 men. The baseline blood pressure averaged 173 +/- 10/86 +/- 6 mmHg (means +/- SD). Median age at which education of patients at school had stopped was 15 years. Men and women who consumed alcohol (28%) had median intakes of 8 and 3 g/day, respectively. The median MMSE score was 29 (range 15-30). The maximum score of 30 was attained by 609 (30%) subjects. Fifty-nine (3%) patients had a MMSE score of 23 or less. The MMSE score decreased with advancing age (r = -0.21, P < 0.001). Both for men and for women, it was positively correlated to the level of education (r = 0.30 and r = 0.32, P < 0.001). For women after adjustment for age and the level of education, the score was correlated negatively to systolic blood pressure (r = -0.07, P < 0.05) but positively to intake of alcohol (r = 0.06, P < 0.05).
In a cohort of elderly patients with isolated systolic hypertension, baseline cognitive function measured in terms of the MMSE score was high, probably due to selective recruitment of patients who were not clinically demented. Blood pressure was a weak contributor to cognitive status compared with age and level of education. Baseline cognitive function of women was negatively and independently correlated to systolic blood pressure.
评估单纯收缩期高血压老年患者无痴呆队列的认知功能及其相关因素。
欧洲老年收缩期高血压试验（Syst-Eur血管性痴呆项目）随机分组期的横断面数据。
16个欧洲国家和以色列。
我们研究了2252名年龄在60 - 100岁（平均70岁）的患者。
简易精神状态检查表（MMSE）以及MMSE评分与人口统计学数据或血压的Spearman相关性。
1474名女性和751名男性成功完成了MMSE检查。基线血压平均为173±10/86±6 mmHg（均值±标准差）。患者停止接受学校教育的年龄中位数为15岁。饮酒的男性和女性（28%）酒精摄入量中位数分别为8克/天和3克/天。MMSE评分中位数为29分（范围15 - 30分）。609名（30%）受试者获得了30分的最高分。59名（3%）患者的MMSE评分为23分或更低。MMSE评分随年龄增长而降低（r = -0.21，P < 0.001）。男性和女性的MMSE评分均与教育水平呈正相关（r = 0.30和r = 0.32，P < 0.001）。对于女性，在调整年龄和教育水平后，评分与收缩压呈负相关（r = -0.07，P < 0.05），但与酒精摄入量呈正相关（r = 0.06，P < 0.05）。
在单纯收缩期高血压老年患者队列中，以MMSE评分衡量的基线认知功能较高，这可能是由于选择性纳入了无临床痴呆的患者。与年龄和教育水平相比，血压对认知状态的影响较小。女性的基线认知功能与收缩压呈负相关且具有独立性。
