组合转录因子
Combinatorial transcription factors.
作者信息
Wolberger C
机构信息
Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA.
出版信息
Curr Opin Genet Dev. 1998 Oct;8(5):552-9. doi: 10.1016/s0959-437x(98)80010-5.
Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATalpha2/MCM1-DNA complex, the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA.
真核转录的组合调控由以特定方式结合形成多蛋白DNA结合复合物的蛋白质介导。最近在理解控制这些复合物组装的蛋白质-蛋白质和蛋白质-DNA相互作用的分子决定因素方面取得了重大进展。已经确定了MATalpha2/MCM1-DNA复合物、与DNA结合的p50/p65 Rel同源结构域异二聚体、NFAT/Fos-Jun/DNA四聚体复合物以及与DNA结合的GABPalpha/beta ETS结构域-锚蛋白重复异二聚体的三维结构。
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