支架附着区域对染色质动力学的促进作用。

Facilitation of chromatin dynamics by SARs.

作者信息

Hart C M, Laemmli U K

机构信息

Departments of Biochemistry and Molecular Biology University of Geneva 30 Quai Ernest-Ansermet, CH-1211, Geneva 4, Switzerland.

出版信息

Curr Opin Genet Dev. 1998 Oct;8(5):519-25. doi: 10.1016/s0959-437x(98)80005-1.

DOI:10.1016/s0959-437x(98)80005-1

PMID:9794825

Abstract

Metaphase chromosome condensation is a dynamic process that must utilize cis elements to form and maintain the final structure. Likewise, cis elements must regulate the accessibility of chromatin domains to protein machines involved in processes such as transcription. Scaffold associated regions appear to play important roles in both of these dynamic processes.

摘要

中期染色体凝聚是一个动态过程，必须利用顺式元件来形成并维持最终结构。同样，顺式元件必须调节染色质结构域对于参与转录等过程的蛋白质机器的可及性。支架相关区域似乎在这两个动态过程中都发挥着重要作用。