RNA聚合酶II全酶中的调控靶点。
Regulatory targets in the RNA polymerase II holoenzyme.
作者信息
Parvin J D, Young R A
机构信息
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Boston, Massachusetts 02115, USA.
出版信息
Curr Opin Genet Dev. 1998 Oct;8(5):565-70. doi: 10.1016/s0959-437x(98)80012-9.
PMID:9794828
Abstract
The RNA polymerase II holoenzyme is the form of polymerase recruited to promoters for protein-coding genes. Several targets of mammalian activators, previously called coactivators, turn out to be subunits of the holoenzyme which activators use to recruit and regulate the holoenzyme. Several of these newly identified holoenzyme components have been implicated in human disease.
摘要
RNA聚合酶II全酶是被招募到蛋白质编码基因启动子上的聚合酶形式。哺乳动物激活因子的几个靶点，以前被称为共激活因子，结果证明是全酶的亚基，激活因子利用它们来招募和调节全酶。这些新发现的全酶成分中有几种与人类疾病有关。
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