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细胞毒性淋巴细胞是如何杀死其靶标的？

How do cytotoxic lymphocytes kill their targets?

作者信息

Shresta S, Pham C T, Thomas D A, Graubert T A, Ley T J

机构信息

Department of Medicine, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

出版信息

Curr Opin Immunol. 1998 Oct;10(5):581-7. doi: 10.1016/s0952-7915(98)80227-6.

DOI:10.1016/s0952-7915(98)80227-6
PMID:9794837
Abstract

CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

摘要

CD8+ 细胞毒性淋巴细胞、自然杀伤细胞和淋巴因子激活的杀伤细胞主要依靠穿孔素/颗粒酶系统来杀伤靶细胞，而CD4+ T细胞则利用Fas和其他机制来诱导细胞死亡。这些途径用于诱导靶细胞凋亡的分子机制可能汇聚于共同的死亡底物。

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How do cytotoxic lymphocytes kill their targets?细胞毒性淋巴细胞是如何杀死其靶标的？
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