肿瘤坏死因子-α在癌症中的临床应用。
Clinical applications of TNF-alpha in cancer.
作者信息
Lejeune F J, Rüegg C, Liénard D
机构信息
Centre Pluridisciplinaire d'Oncologie, Centre Hospitalier UniversitaireVaudois (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
出版信息
Curr Opin Immunol. 1998 Oct;10(5):573-80. doi: 10.1016/s0952-7915(98)80226-4.
High-dose TNF-alpha plus chemotherapy, with or without IFN-gamma, can be safely administered regionally through isolated limb perfusion. This procedure produced between 70% and 80% complete remission in cases of in transit melanoma metastases and between 25% and 36% complete remission in cases of inextirpable soft-tissue sarcomas. Dual targeting is involved; TNF-alpha and IFN-gamma induce apoptosis of angiogenic endothelium, while melphalan induces apoptosis of tumour cells.
高剂量肿瘤坏死因子-α加化疗，无论是否联合干扰素-γ，均可通过隔离肢体灌注安全地进行局部给药。该方法在治疗进展期黑色素瘤转移时的完全缓解率为70%至80%，在治疗无法切除的软组织肉瘤时的完全缓解率为25%至36%。此过程涉及双重靶向作用；肿瘤坏死因子-α和干扰素-γ可诱导血管生成内皮细胞凋亡，而美法仑可诱导肿瘤细胞凋亡。
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