Rodrigues E G, Zavala F, Nussenzweig R S, Wilson J M, Tsuji M
Department of Medical and Molecular Parasitology, New York University School of Medicine, NY 10010, USA.
Vaccine. 1998 Nov;16(19):1812-7. doi: 10.1016/s0264-410x(98)00181-9.
The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.
将先前构建的表达约氏疟原虫环子孢子蛋白（CS）的复制缺陷型重组腺病毒的免疫原性与经辐照的子孢子的免疫原性进行了比较。我们发现，用单剂量这种重组腺病毒免疫BALB/c小鼠，与用经辐照的子孢子免疫相比，诱导出的CS特异性T细胞反应要强得多。更重要的是，我们发现这种重组腺病毒诱导的保护性免疫水平与经辐照的子孢子诱导的相似或更高，引发了对疟疾感染的明显抗性。
