Caporossi A, Casprini F, Tosi G M, Balestrazzi A, Stumpo M, Toti P
Dipartimento di Scienze Oftalmologiche e Neurochirurgiche, Università degli Studi di Siena, Italy.
J Cataract Refract Surg. 1998 Oct;24(10):1343-6. doi: 10.1016/s0886-3350(98)80226-5.
To determine the histology and immunohistochemistry of anterior capsule fibrosis.
Department of Ophthalmology and Neurosurgery and Institute of Pathology, University of Siena, Siena, Italy.
Tissue sections from 3 patients with anterior capsule fibrosis after phacoemulsification and intraocular lens implantation were examined histologically.
The proliferating tissue was devoid of vessels and composed of dense fibrous tissue and numerous activated fibroblasts with contractile capacity (myofibroblasts). No TGF-beta, which is the most important cytokine in modulating myofibroblasts, was present in the fibrotic tissue.
The absence of the cytokine TGF-beta and inflammatory cells in the proliferating tissue confirms the unique character of the reparative activity within the eye.
确定前囊膜纤维化的组织学和免疫组织化学特征。
意大利锡耶纳大学眼科与神经外科以及病理研究所。
对3例白内障超声乳化吸除联合人工晶状体植入术后发生前囊膜纤维化患者的组织切片进行组织学检查。
增殖组织无血管，由致密纤维组织和大量具有收缩能力的活化成纤维细胞（肌成纤维细胞）组成。纤维化组织中不存在调节肌成纤维细胞的最重要细胞因子转化生长因子-β（TGF-β）。
增殖组织中细胞因子TGF-β和炎性细胞的缺失证实了眼内修复活动的独特性质。
