Iwakura A, Komeda M, Fujita M
Department of Cardiovascular Surgery, Kyoto University.
Nihon Rinsho. 1998 Oct;56(10):2504-8.
The presence or absence of collateral circulation significantly impacts the natural history of coronary artery disease. Collateral growth involves two different mechanism; capillary collaterals develop by sprouting (angiogenesis) and muscular collaterals develop in situ from preexisting arterioles (arteriogenesis). The process is mediated by various angiogenic growth factors such as VEGF, FGFs, IGF-1 and PDGF. Although these growth factors have been studied extensively, controversies still exist as to whether angiogenesis depends on increased supply of these growth factors or their receptors are upregulated by the underlying pathological situation. An increased understanding of the basic biology of collateral vessel development would be instrumental in the establishment of therapeutic angiogenesis.
侧支循环的存在与否对冠状动脉疾病的自然病程有显著影响。侧支生长涉及两种不同机制；毛细血管侧支通过芽生（血管生成）形成，而肌性侧支由先前存在的小动脉原位发育（动脉生成）。该过程由多种血管生成生长因子介导，如血管内皮生长因子（VEGF）、成纤维细胞生长因子（FGFs）、胰岛素样生长因子-1（IGF-1）和血小板衍生生长因子（PDGF）。尽管对这些生长因子已进行了广泛研究，但关于血管生成是依赖于这些生长因子供应增加还是其受体因潜在病理状况而上调仍存在争议。对侧支血管发育基础生物学的深入理解将有助于治疗性血管生成的建立。
