Buschmann Ivo, Katzer Eva, Bode Christoph
Albert Ludwigs University Freiburg Medical Clinic III, Research Group for Experimental and Clinical Arteriogenesis, Department for Cardiology and Angiology, Breisacher Str. 66, Germany.
Basic Res Cardiol. 2003 Feb;98(1):1-5. doi: 10.1007/s00395-003-0388-9.
The role of the collateral circulation has been controversially discussed over many decades. With the availability of purified growth factors such as the fibroblast growth factors several studies provided data, that the growth of collateral arteries, termed arteriogenesis, is not limited to its natural timecourse. When applied in experimental models FGF in particular led to a significant increase in collateral conductance upon arterial occlusion. Thus the proliferation of preexisting bypassing arterioles could be enhanced therapeutically. The purpose of this review is to discuss the physiological importance of different kinds of vascular growth (e.g. vasculogenesis, angiogenesis, arteriogenesis) to enhance blood flow to ischemic limbs or the heart. It is outlined that large conductance arteries rather than capillary networks are needed to compensate for perfusion deficits due to atherosclerotic stenosis or occlusion.
几十年来，侧支循环的作用一直是一个有争议的讨论话题。随着纯化生长因子如成纤维细胞生长因子的出现，多项研究提供的数据表明，侧支动脉的生长，即动脉生成，并不局限于其自然进程。当在实验模型中应用时，特别是FGF会导致动脉闭塞后侧支传导显著增加。因此，预先存在的旁路小动脉的增殖可以通过治疗得到增强。这篇综述的目的是讨论不同类型血管生长（如血管发生、血管生成、动脉生成）对增加缺血肢体或心脏血流量的生理重要性。文中概述，需要大传导动脉而非毛细血管网络来补偿由于动脉粥样硬化狭窄或闭塞导致的灌注不足。
