Links J M
Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21205, USA.
Q J Nucl Med. 1998 Sep;42(3):158-65.
Emission computed tomography provides an opportunity to quantify neurotransmitter-neuroreceptor systems in vivo. In order to do so, very high image quality and quantitative accuracy are required. Quantitation of receptor systems involves considerations of physical effects (such as finite spatial resolution, scatter, and attenuation), instrumentation design (such as spatial sampling), image processing (such as filtering), and data analysis (such as kinetic modeling). Appropriate application of these considerations can lead to useful results, but emerging approaches promise even greater levels of accuracy and precision.
发射计算机断层扫描为体内神经递质-神经受体系统的定量分析提供了契机。为实现这一目的，需要非常高的图像质量和定量准确性。受体系统的定量分析涉及到物理效应（如有限的空间分辨率、散射和衰减）、仪器设计（如空间采样）、图像处理（如滤波）以及数据分析（如动力学建模）等方面的考量。恰当地运用这些考量因素能够得出有用的结果，但新兴方法有望实现更高水平的准确性和精确性。
