Furman-Haran E, Grobgeld D, Margalit R, Degani H
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Clin Cancer Res. 1998 Oct;4(10):2299-304.
Variations in the cellular volume fraction and in the microvascular permeability of MCF7 human breast tumors were used to assess response to tamoxifen. These pathophysiological features were mapped by applying the three-time-point, contrast-enhanced, high resolution magnetic resonance imaging method (H. Degani et al, Nat. Med., 3: 780-782, 1997). Short-term treatment with tamoxifen caused a highly significant increase in the fraction of pixels displaying intermediate contrast agent clearance pattern and a significant increase in the fraction of pixels displaying high rate of contrast agent entrance. These changes resulted from a marked rise in the extracellular volume fraction, indicating increased necrosis, and from an augmentation in the microvascular permeability, predominantly in the vicinity of the high extracellular volume fraction areas, as a result of stress-induced angiogenesis.
通过MCF7人乳腺肿瘤的细胞体积分数和微血管通透性的变化来评估他莫昔芬的疗效。这些病理生理特征通过应用三点对比增强高分辨率磁共振成像方法进行测绘（H. Degani等人，《自然医学》，第3卷，第780 - 782页，1997年）。他莫昔芬短期治疗导致显示中等造影剂清除模式的像素比例显著增加，以及显示高造影剂进入率的像素比例显著增加。这些变化源于细胞外体积分数的显著升高，表明坏死增加，以及微血管通透性的增强，主要发生在高细胞外体积分数区域附近，这是应激诱导血管生成的结果。
