Serour G I, Aboulghar M, Mansour R, Sattar M A, Amin Y, Aboulghar H
The Egyptian IVF & ET Center, Maadi, Cairo.
Fertil Steril. 1998 Oct;70(4):638-42. doi: 10.1016/s0015-0282(98)00250-7.
To investigate the incidence of complications in the use of assisted reproductive technology in the management of infertile couples.
Retrospective study.
The Egyptian IVF & ET Center, Maadi, Cairo, Egypt.
PATIENT(S): Two thousand nine hundred twenty-four patients underwent IVF-ET or intracytoplasmic sperm injection (ICSI) in 3,500 cycles.
INTERVENTION(S): IVF-ET, ICSI, ejaculate sperm, epididymal sperm aspiration, and testicular sperm extraction.
MAIN OUTCOME MEASURE(S): Complications of the procedure and complications of pregnancy in 702 patients.
RESULT(S): Fifteen hundred ovum pickups for IVF-ET and 2,000 ovum pickups for ICSI were performed. Clinical pregnancy occurred in 1,078 patients (30.8%). Four groups of complications were identified. Complications of the procedure occurred in 291 patients (8.3%). Complications of pregnancy included ectopic pregnancy in 1.9%, heterotopic pregnancy in 0.2%. abortion in 20.6%, multiple pregnancy in 28%, pregnancy-induced hypertension in 10%, preterm labor in 21.5%, low birth weight in 30.5%, and intrauterine death in 2%. Coincidental complications occurred in five patients (0.15%). Other complications that were difficult to measure included psychological breakdown and socioeconomic problems.
CONCLUSION(S): Assisted reproductive technology is effective for the management of infertility and has an acceptable incidence of complications. Complications rarely endanger the life of the patient. When this line of treatment is offered, the indications should be definitive. Patients should be monitored properly and measures should be taken to minimize the incidence of complications.
调查辅助生殖技术用于治疗不孕夫妇时并发症的发生率。
回顾性研究。
埃及开罗马阿迪的埃及体外受精与胚胎移植中心。
2924例患者接受了3500个周期的体外受精-胚胎移植（IVF-ET）或卵胞浆内单精子注射（ICSI）。
IVF-ET、ICSI、射出精子、附睾精子抽吸和睾丸精子提取。
702例患者的手术并发症和妊娠并发症。
进行了1500次IVF-ET取卵和2000次ICSI取卵。1078例患者（30.8%）临床妊娠。确定了四组并发症。291例患者（8.3%）发生手术并发症。妊娠并发症包括异位妊娠1.9%、同期复孕0.2%、流产20.6%、多胎妊娠28%、妊娠高血压10%、早产21.5%、低出生体重30.5%和宫内死亡2%。5例患者（0.15%）发生合并并发症。其他难以衡量的并发症包括心理崩溃和社会经济问题。
辅助生殖技术对治疗不孕症有效，并发症发生率可接受。并发症很少危及患者生命。提供这种治疗方法时，适应证应明确。应适当监测患者，并采取措施尽量降低并发症发生率。
