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干燥综合征患者唾液和血清透明质酸浓度

Salivary and serum hyaluronic acid concentrations in patients with Sjögren's syndrome.

作者信息

Tishler M, Yaron I, Shirazi I, Yaron M

机构信息

Department of Rheumatology, Tel Aviv-Souraski Medical Centre, Ichilov Hospital, Tel Aviv, Israel.

出版信息

Ann Rheum Dis. 1998 Aug;57(8):506-8. doi: 10.1136/ard.57.8.506.

DOI:10.1136/ard.57.8.506
PMID:9797560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1752723/
Abstract

OBJECTIVE

To evaluate salivary hyaluronic acid (HA) concentration in patients with primary Sjögren's syndrome (SS).

METHODS

Salivary and serum HA concentrations were evaluated using a radiometric assay. Thirty nine patients with SS served as the study group and their results were compared with 19 patients having clinical symptoms and signs of dry mouth and with 10 normal controls.

RESULTS

Salivary HA concentrations were significantly increased (p < 0.05) in the 39 patients with SS compared with the 19 patients with dry mouth and the 10 normal controls (240.7 (38.5) v 99.8 (14.6) and 91.3 (7.9) ng/ml, respectively) (mean (SEM)). No significant differences were noted in the serum HA concentrations between the three groups (42 (3.9) v 36.3 (4.1) and 32 (4.3) ng/ml, respectively) (mean (SEM)). No correlation could be found between salivary HA concentrations and the focus score of lip biopsies, nor between salivary HA concentrations and erythrocyte sedimentation rate or other serological tests.

CONCLUSION

Increased salivary HA concentrations can serve as a marker of local inflammation and may be of value in the diagnosis of SS.

摘要

目的

评估原发性干燥综合征（SS）患者唾液透明质酸（HA）浓度。

方法

采用放射免疫分析法评估唾液和血清HA浓度。39例SS患者作为研究组，将其结果与19例有口干临床症状和体征的患者以及10例正常对照者进行比较。

结果

与19例口干患者和10例正常对照者相比，39例SS患者的唾液HA浓度显著升高（p<0.05）（分别为240.7（38.5）、99.8（14.6）和91.3（7.9）ng/ml）（均值（标准误））。三组血清HA浓度无显著差异（分别为42（3.9）、36.3（4.1）和32（4.3）ng/ml）（均值（标准误））。唾液HA浓度与唇活检灶性评分之间、唾液HA浓度与红细胞沉降率或其他血清学检查之间均未发现相关性。

结论

唾液HA浓度升高可作为局部炎症的标志物，可能对SS的诊断有价值。