Malmros B, Mortensen L, Jensen M B, Charles P
Department of Physiotherapy, Aarhus Amtssygehus, Denmark.
Osteoporos Int. 1998;8(3):215-21. doi: 10.1007/s001980050057.
The aim of this placebo-controlled, randomized, single-masked study was to establish the effects of a 10-week ambulatory exercise programme for osteoporotic patients on pain, use of analgesics, functional status, quality of life, balance and muscle strength. Fifty-three ambulatory postmenopausal women with at least one spinal crush fracture and pains within the last 3 years were randomized for physiotherapeutic training twice a week for 10 weeks or no training. The training included general training of balance and muscle strength, with stabilization of the lumbar spine. The participants were tested at baseline, week 5 and week 10 with a balance test, muscle strength test and questionnaires on pain, use of analgesics, functional status and quality of life. Twelve weeks after the supervised training had finished (week 22) they answered the same questionnaires. The study groups were comparable at baseline. The training group had a significant reduction in use of analgesics (p = 0.02) and pain level (p = 0.01) during the training period. Distribution of functional score improved; the improvement was reduced at week 22. Quality of life score improved significantly throughout the study (p = 0.0008), even after week 22. Balance improved non-significantly (p = 0.08). Quadriceps muscle strength improved significantly after 5 weeks (p = 0.04). Back extensor muscle strength improved almost significantly (p = 0.09). In conclusion, this training programme for osteoporotic patients improved balance and level of daily function and decreased experience of pain and use of analgesics. Quality of life was improved even beyond the active training period.
这项安慰剂对照、随机、单盲研究的目的是确定一项为期10周的骨质疏松症患者门诊运动计划对疼痛、镇痛药使用、功能状态、生活质量、平衡能力和肌肉力量的影响。53名至少有一处脊柱压缩性骨折且在过去3年内有疼痛症状的绝经后门诊女性被随机分为两组，一组每周接受两次物理治疗训练，为期10周，另一组不接受训练。训练包括平衡和肌肉力量的常规训练以及腰椎的稳定训练。参与者在基线、第5周和第10周接受平衡测试、肌肉力量测试以及关于疼痛、镇痛药使用、功能状态和生活质量的问卷调查。在监督训练结束12周后（第22周），他们再次回答相同的问卷。研究组在基线时具有可比性。训练组在训练期间镇痛药的使用（p = 0.02）和疼痛程度（p = 0.01）显著降低。功能评分的分布有所改善；在第22周时改善程度有所下降。生活质量评分在整个研究过程中显著提高（p = 0.0008），即使在第22周之后也是如此。平衡能力有不显著的改善（p = 0.08）。股四头肌力量在5周后显著提高（p = 0.04）。背部伸肌力量几乎有显著提高（p = 0.09）。总之，这项针对骨质疏松症患者的训练计划改善了平衡能力和日常功能水平，减少了疼痛体验和镇痛药的使用。即使在积极训练期之后，生活质量也得到了提高。
