利培酮与氟哌啶醇对难治性精神分裂症患者反应时间、手部灵活性及运动学习的影响
Risperidone vs. haloperidol on reaction time, manual dexterity, and motor learning in treatment-resistant schizophrenia patients.
作者信息
Kern R S, Green M F, Marshall B D, Wirshing W C, Wirshing D, McGurk S, Marder S R, Mintz J
机构信息
UCLA Department of Psychiatry and Biobehavioral Sciences, USA.
出版信息
Biol Psychiatry. 1998 Oct 15;44(8):726-32. doi: 10.1016/s0006-3223(98)00088-2.
BACKGROUND
The present study compared the effects of risperidone vs. haloperidol on reaction time, manual dexterity, and two types of motor learning in a sample of treatment-resistant schizophrenia patients.
METHODS
Fifty-six DSM-III-R diagnosed schizophrenia inpatients participated in a randomized, double-blind comparison of risperidone vs. haloperidol. Measures of reaction time, manual dexterity, motor sequence learning, and gross motor learning were administered at baseline, after 4 weeks of fixed-dose medication, and after 4 weeks of flexible-dose medication.
RESULTS
The results indicated that patients receiving risperidone showed greater improvement in reaction time and manual dexterity than patients receiving haloperidol. After covarying symptom changes and movement disorder ratings, the results remained significant. The two treatment groups did not differ on either measure of motor learning.
CONCLUSIONS
The differences in performance in reaction time and manual dexterity may be due to a specific beneficial effect of risperidone, as opposed to a general reduction in extrapyramidal symptom liability, compared to haloperidol.
背景
本研究比较了利培酮与氟哌啶醇对难治性精神分裂症患者样本的反应时间、手部灵活性及两种运动学习类型的影响。
方法
56名符合DSM-III-R诊断标准的精神分裂症住院患者参与了一项利培酮与氟哌啶醇的随机双盲对照研究。在基线期、固定剂量用药4周后及灵活剂量用药4周后，分别进行反应时间、手部灵活性、运动序列学习及粗大运动学习的测量。
结果
结果表明，接受利培酮治疗的患者在反应时间和手部灵活性方面比接受氟哌啶醇治疗的患者有更大改善。在对症状变化和运动障碍评分进行协变量调整后，结果仍然显著。两个治疗组在任何一项运动学习测量上均无差异。
结论
与氟哌啶醇相比，反应时间和手部灵活性表现的差异可能归因于利培酮的特定有益作用，而非锥体外系症状易感性的普遍降低。
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