下唇原发性促纤维增生性嗜神经性黑色素瘤：一种具有凶险行为的肿瘤。
De novo desmoplastic neurotropic melanoma of the lower lip: a neoplasm with ominous behavior.
作者信息
Madrigal B, Fresno M F, Junquera L, Veiga M, Ablanedo P, Herrero A
机构信息
Hospital Covadonga (HCA), University of Oviedo.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Oct;86(4):452-6. doi: 10.1016/s1079-2104(98)90372-9.
Desmoplastic neurotropic melanoma represents a rare histologic variant of malignant melanoma that is characterized by a proliferation of spindle cells in a densely collagenous stroma with pronounced neurotropism. A 60-year-old man appeared for evaluation of a mass in the lower lip. The labial mucosa was intact, and the lesion had been present for 2 months. The tumor was surgically removed, and after immunohistochemical and ultrastructural analysis it was diagnosed as desmoplastic neurotropic melanoma. The tumor recurred 6 months later, with involvement of the inferior alveolar nerve.
促纤维增生性嗜神经性黑色素瘤是恶性黑色素瘤一种罕见的组织学变异型，其特征是在富含胶原的致密间质中梭形细胞增生，并具有明显的嗜神经性。一名60岁男性因下唇肿物前来评估。唇黏膜完整，病变已存在2个月。肿瘤经手术切除，经免疫组化和超微结构分析后诊断为促纤维增生性嗜神经性黑色素瘤。6个月后肿瘤复发，累及下牙槽神经。
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