螺内酯与急性高原病

Spironolactone and acute mountain sickness.

作者信息

Currie T T, Carter P H, Champion W L, Fong G, Francis J K, McDonald I H, Newing R K, Nunn I N, Sisson R N, Sussex M, Zacharin R F

出版信息

Med J Aust. 1976 Jul 31;2(5):168-70.

PMID:979834

Abstract

Thirteen adults trekking in Nepal in 1974 to altitudes between 4,300 m and 5,500 m remained free from acute mountain sickness while taking spironolactone as a prophylactic measure. Two years previously five of these adults trekking at similar altitudes, but without treatment, had suffered from acute mountain sickness. The regime used was spironolactone in a dosage of 25 mg three times a day for two days preceding and during the periods spent at altitudes above 3,000 m.

摘要

1974年，13名成年人在尼泊尔徒步旅行至海拔4300米至5500米之间的地区，在服用螺内酯作为预防措施期间未患急性高山病。两年前，其中5名成年人在类似海拔地区徒步旅行，但未接受治疗，患上了急性高山病。采用的方案是在海拔3000米以上地区停留之前及期间，每天服用3次螺内酯，每次25毫克，共服用两天。