Fogari R, Zoppi A, Corradi L, Mugellini A, Poletti L, Lusardi P
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
Am J Hypertens. 1998 Oct;11(10):1244-7. doi: 10.1016/s0895-7061(98)00139-3.
To evaluate the effect of antihypertensive treatment on sexual activity, 90 hypertensive men, aged 40 to 49 years, all married and without history of sexual dysfunction were treated with 100 mg of atenolol or 20 mg of lisinopril for 16 weeks, according to a double-blind, randomized, cross-over design. During the first month of therapy, sexual activity, assessed as number of sexual intercourse episodes per month, significantly declined with both atenolol (from 7.8 +/- 4.3 to 4.5 +/- 2.8, P < .01 v placebo) and lisinopril (from 7.1 +/- 4.0 to 5.0 +/- 2.5, P < .05 v placebo). Ongoing with the treatment, sexual activity tended toward recovery in the lisinopril (7.7 +/- 4.0 sexual intercourse episodes per month, P = NS v placebo), but not in the atenolol group (4.2 +/- 2.8, P < .01 v placebo), with a statistically significant difference between the two drugs (P < .01). The percentage of patients who complained of sexual dysfunction symptoms was significantly higher in the atenolol- than in the lisinopril-treated group (17% v 3%, P < .05). These findings suggest that atenolol induces a chronic worsening of sexual activity, whereas lisinopril causes only a temporary decline.
为评估抗高血压治疗对性功能的影响，按照双盲、随机、交叉设计，对90名年龄在40至49岁之间、均已婚且无性功能障碍病史的高血压男性患者，给予100毫克阿替洛尔或20毫克赖诺普利治疗16周。在治疗的第一个月，以每月性交次数评估的性功能，在使用阿替洛尔（从7.8±4.3降至4.5±2.8，与安慰剂相比P<0.01）和赖诺普利（从7.1±4.0降至5.0±2.5，与安慰剂相比P<0.05）时均显著下降。随着治疗的持续进行，赖诺普利组的性功能有恢复趋势（每月7.7±4.0次性交，与安慰剂相比P=无显著差异），但阿替洛尔组没有（4.2±2.8，与安慰剂相比P<0.01），两种药物之间存在统计学显著差异（P<0.01）。抱怨性功能障碍症状的患者百分比在阿替洛尔治疗组显著高于赖诺普利治疗组（17%对3%，P<0.05）。这些发现表明，阿替洛尔会导致性功能的慢性恶化，而赖诺普利仅引起暂时下降。
