Gharavi A G, Diamond J A, Goldman A Y, Coplan N L, Jhang J S, Steinmetz M, Goldsmith R, Phillips R A
Hypertension Section, Cardiovascular Institute, Mount Sinai School of Medicine, New York City, New York 10029-6574, USA.
Am J Hypertens. 1998 Oct;11(10):1252-7. doi: 10.1016/s0895-7061(98)00138-1.
We evaluated the impact of diastolic function and gender on exercise capacity in sedentary, untreated hypertensive subjects (34 men, 23 women) using echocardiography and a bicycle ergometry with measurement of oxygen consumption (VO2). In men, peak (A) mitral inflow velocity and left ventricular (LV) mass were inversely related to peak VO2 (r = -0.64) and maximal workload (r = -0.57) and were the sole independent determinants of exercise capacity. In women, there was no relationship between any echocardiographic measure and exercise capacity. Thus, LV mass and Doppler-determined diastolic function predict maximal VO2 in hypertensive men but not in women. This finding may be related to gender differences in the contribution of diastolic filling to exercise capacity or may reflect limitations of resting Doppler echocardiography to predict exercise diastolic filling in hypertensive women.
我们使用超声心动图和测量耗氧量（VO₂）的自行车测力计，评估了舒张功能和性别对久坐不动、未经治疗的高血压受试者（34名男性，23名女性）运动能力的影响。在男性中，二尖瓣流入峰值速度（A）和左心室（LV）质量与峰值VO₂（r = -0.64）和最大工作量（r = -0.57）呈负相关，并且是运动能力的唯一独立决定因素。在女性中，任何超声心动图测量指标与运动能力之间均无关联。因此，左心室质量和多普勒测定的舒张功能可预测高血压男性的最大VO₂，但不能预测女性的。这一发现可能与舒张期充盈对运动能力贡献的性别差异有关，或者可能反映了静息多普勒超声心动图在预测高血压女性运动时舒张期充盈方面的局限性。
