Peng H, Chen H
Department of Surgery, Taichung Veterans General Hospital, 160, section 3, Taichung Kang Road, Taichung, Taiwan, Republic of China 407.
Pediatr Surg Int. 1998 Oct;13(8):572-5. doi: 10.1007/s003830050406.
Most previous studies have shown that the digestive tract of the neonate is rapidly and heavily colonized in the first few days of life, but all the studies so far used either feces or rectal swabs to isolate and identify bacterial colonization. The exact timing of intestinal colonization is not yet certain. From a retrospective analysis of 24 neonates with intestinal perforation and a prospective study of 30 ill neonates aged less than 10 days who recieved intestinal-tract operations, we found that the incidence of bacterial growth from small-and large-bowel specimens was significantly lower within 48 h after birth and the intestinal tract was almost completely sterile within 24 h after delivery. Most of the bacteria were aerobic gram-negative bacilli, and the most common species was Escherichia coli. Although our results may not represent conditions in the normal neonate, knowledge of bowel colonization in such patients will be helpful for further management.
大多数先前的研究表明，新生儿的消化道在出生后的头几天内会迅速且大量地被细菌定植，但迄今为止所有研究均使用粪便或直肠拭子来分离和鉴定细菌定植情况。肠道定植的确切时间尚不确定。通过对24例肠穿孔新生儿的回顾性分析以及对30例年龄小于10天接受肠道手术的患病新生儿的前瞻性研究，我们发现出生后48小时内小肠和大肠标本中细菌生长的发生率显著较低，并且在分娩后24小时内肠道几乎完全无菌。大多数细菌是需氧革兰氏阴性杆菌，最常见的菌种是大肠杆菌。尽管我们的结果可能并不代表正常新生儿的情况，但了解此类患者的肠道定植情况将有助于进一步的治疗。
