与果蝇多梳样蛋白相关的Tctex3在雄性生殖细胞中表达，并定位到小鼠t-复合体。

Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex.

作者信息

Kawakami S, Mitsunaga K, Kikuti Y Y, Ando A, Inoko H, Yamamura K, Abe K

机构信息

Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, 4-24-1 Kuhonji, Kumamoto 862, Japan.

出版信息

Mamm Genome. 1998 Nov;9(11):874-80. doi: 10.1007/s003359900886.

DOI:10.1007/s003359900886

PMID:9799836

Abstract

Tctex3 showing restricted expression in male germ cells has been isolated during the process of chromosome walking in the mouse t-complex region. The total sequence of Tctex3 cDNA predicts a protein of 580 amino acids with two C4HC3 type PHD fingers. The region containing this conserved motif is shared among members of the Polycomblike proteins that include the mouse M96 and Drosophila Polycomblike. A partial cDNA for a human homolog of Tctex3, HUTEX3, has also been isolated. Mouse Tctex3 gene was mapped adjacent to Tsc2 gene on mouse Chromosome (Chr) 17, and HUTEX3 was located closely to HSET gene in the HLA class II region of chromosome 6.

摘要

在小鼠t复合区域的染色体步移过程中，已分离出在雄性生殖细胞中呈限制性表达的Tctex3。Tctex3 cDNA的完整序列预测其编码一个含两个C4HC3型PHD指结构域的580个氨基酸的蛋白质。包含此保守基序的区域存在于Polycomblike蛋白家族成员中，其中包括小鼠M96和果蝇Polycomblike。还分离出了Tctex3人类同源物HUTEX3的部分cDNA。小鼠Tctex3基因定位于小鼠第17号染色体（Chr）上与Tsc2基因相邻的位置，而HUTEX3则紧密定位于6号染色体HLA II类区域中的HSET基因附近。