可溶性纤维在高胆固醇血症治疗中的潜在作用。
The potential role of soluble fibre in the treatment of hypercholesterolaemia.
作者信息
Coats A J
机构信息
Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, UK.
出版信息
Postgrad Med J. 1998 Jul;74(873):391-4. doi: 10.1136/pgmj.74.873.391.
The three major modifiable coronary risk factors are smoking, hypertension, and hypercholesterolaemia. Serum cholesterol levels are above the desirable level of 5.2 mmol/l in 79% of men and 65% of women aged between 35 and 50 years and thus are an important target for intervention. In this paper, the role of nonpharmacological intervention with soluble fibre in treating mild to moderate primary hypercholesterolaemia is reviewed. Evidence from controlled studies shows that soluble fibre can be effective in lowering cholesterol by clinically significant amounts. It is stressed, however, that risk factors for coronary heart disease are interactive and attention is shifting to addressing multiple rather that individual factors.
三种主要的可改变的冠心病危险因素是吸烟、高血压和高胆固醇血症。在35至50岁的男性中，79%的人血清胆固醇水平高于理想水平5.2 mmol/l；在该年龄段的女性中，这一比例为65%。因此，血清胆固醇水平是重要的干预靶点。本文综述了可溶性纤维非药物干预在治疗轻至中度原发性高胆固醇血症中的作用。对照研究的证据表明，可溶性纤维能有效降低胆固醇，且降低幅度具有临床意义。然而，需要强调的是，冠心病的危险因素相互作用，目前人们的关注点正转向解决多种危险因素而非单一因素。
Zotero 插件