Rosen M I, Pearsall H R, Kosten T R
Yale University, Department of Psychiatry, New Haven, CT 06519, USA.
Drug Alcohol Depend. 1998 Oct 1;52(2):173-6. doi: 10.1016/s0376-8716(98)00057-x.
We hypothesized that lamotrigine, a putative glutamate release antagonist, would attenuate glutamate-mediated signs of opiate withdrawal. Seven heroin-dependent subjects were hospitalized, stabilized on oral levorphanol 6 mg three times daily, and thrice underwent withdrawal precipitated by naloxone 0.4 mg intravenously. Lamotrigine (placebo, 250 mg, and 500 mg) was randomly given as a pretreatment 6 h before naloxone. Lamotrigine did not significantly attenuate any measure of opiate withdrawal. Lamotrigine was well-tolerated in subjects, although one did develop an allergic rash.
我们推测，拉莫三嗪作为一种假定的谷氨酸释放拮抗剂，会减轻谷氨酸介导的阿片类药物戒断症状。七名海洛因依赖者住院治疗，每天口服3次6毫克左啡诺以维持稳定状态，然后三次接受静脉注射0.4毫克纳洛酮引发的戒断反应。在注射纳洛酮前6小时，随机给予拉莫三嗪（安慰剂、250毫克和500毫克）进行预处理。拉莫三嗪并未显著减轻任何阿片类药物戒断症状。尽管有一名受试者出现了过敏皮疹，但拉莫三嗪在受试者中耐受性良好。
