Turner C D, Kuznetsov D, Contreras B A, Gerber G S
Department of Surgery, University of Chicago Pritzker School of Medicine, Illinois 60637, USA.
Tech Urol. 1998 Sep;4(3):136-40.
The aim of this study was to correlate the results of the urodynamic measures, detrusor contraction duration (DCD) and detrusor contraction index (DCI), with voiding symptoms in untreated men with lower urinary tract symptoms (LUTS) and in men treated with doxazosin. Ninety-one men with untreated LUTS underwent urodynamic evaluation. DCD (duration of detrusor contraction in seconds), DCI (interval, in seconds, that urine is passed divided by the total duration of the bladder contraction), and standard urodynamic measures of obstruction were determined. The urodynamic findings were correlated with the severity of voiding symptoms as assessed by the International Prostate Symptom Score (I-PSS). Fifty of these men were treated subsequently with 4 mg of doxazosin for 3 months and then underwent repeat urodynamic evaluation, in which changes in symptom score and urodynamic results were analyzed. DCD was the only urodynamic measure that correlated significantly with the I-PSS results in untreated patients. Although DCD, detrusor pressure at maximum flow, and the Abrams-Griffiths number decreased in men treated with doxazosin, only DCI and symptom score improved significantly after treatment for 3 months. No urodynamic parameter was useful in predicting the likelihood of a favorable response to treatment with doxazosin. DCD and DCI may be useful urodynamic measures in untreated men with LUTS and in those treated with doxazosin. Further study of these parameters is warranted.
本研究的目的是将尿动力学测量结果，即逼尿肌收缩持续时间（DCD）和逼尿肌收缩指数（DCI），与未经治疗的下尿路症状（LUTS）男性及接受多沙唑嗪治疗的男性的排尿症状相关联。91名未经治疗的LUTS男性接受了尿动力学评估。测定了DCD（逼尿肌收缩持续时间，以秒为单位）、DCI（尿液排出间隔时间，以秒为单位，除以膀胱收缩总持续时间）以及标准的梗阻性尿动力学测量指标。尿动力学检查结果与国际前列腺症状评分（I-PSS）评估的排尿症状严重程度相关。其中50名男性随后接受了4毫克多沙唑嗪治疗3个月，然后进行重复尿动力学评估，分析症状评分和尿动力学结果的变化。DCD是唯一与未经治疗患者的I-PSS结果显著相关的尿动力学测量指标。尽管接受多沙唑嗪治疗的男性的DCD、最大尿流率时的逼尿肌压力以及艾布拉姆斯-格里菲思数值均下降，但仅DCI和症状评分在治疗3个月后有显著改善。没有尿动力学参数可用于预测对多沙唑嗪治疗产生良好反应的可能性。DCD和DCI可能是未经治疗的LUTS男性及接受多沙唑嗪治疗男性有用的尿动力学测量指标。有必要对这些参数进行进一步研究。
