衰老与对破伤风类毒素的免疫反应：对抗抗原刺激的细胞免疫反应频率和水平降低。
Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation.
作者信息
Schatz D, Ellis T, Ottendorfer E, Jodoin E, Barrett D, Atkinson M
机构信息
Departments of Pediatrics, University of Florida, Gainesville, Florida.
出版信息
Clin Diagn Lab Immunol. 1998 Nov;5(6):894-6. doi: 10.1128/CDLI.5.6.894-896.1998.
Abstract
The period of efficacious immune reactivity afforded by tetanus immunization and the need for continuing some forms of tetanus vaccination programs have been the subjects of recent debates. Our studies demonstrate that the level of antitetanus immunity based on immunological memory (i.e., cellular immune responsiveness) varies dramatically as a function of age, with older individuals constituting a population which is increasingly susceptible to tetanus infection.
摘要
破伤风免疫所提供的有效免疫反应期以及持续某些形式破伤风疫苗接种计划的必要性一直是近期辩论的主题。我们的研究表明，基于免疫记忆（即细胞免疫反应性）的抗破伤风免疫水平会随着年龄的变化而显著不同，年龄较大的个体越来越容易感染破伤风。
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Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation.衰老与对破伤风类毒素的免疫反应：对抗抗原刺激的细胞免疫反应频率和水平降低。
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